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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
9.09
Human Site:
S127
Identified Species:
14.29
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
S127
L
T
D
E
N
A
L
S
G
N
E
E
L
T
V
Chimpanzee
Pan troglodytes
XP_509323
803
92478
S127
L
T
D
E
N
A
L
S
G
N
E
E
L
T
V
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
S127
L
T
D
E
N
A
L
S
G
N
E
E
L
T
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
A127
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
Rat
Rattus norvegicus
Q66HD0
804
92752
A127
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
A145
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
Chicken
Gallus gallus
P08110
795
91537
A126
L
T
D
E
N
A
L
A
G
N
E
E
L
T
V
Frog
Xenopus laevis
NP_001083114
805
92996
A127
L
T
D
E
N
A
L
A
A
N
E
E
L
T
I
Zebra Danio
Brachydanio rerio
Q90474
725
83300
I101
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
N94
T
K
S
D
L
V
N
N
L
G
T
I
A
K
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
I79
K
E
E
K
T
L
T
I
M
D
T
G
I
G
M
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
A126
T
S
L
T
D
K
A
A
L
D
A
T
E
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
G92
T
L
S
I
I
D
S
G
V
G
M
T
K
S
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
V128
L
A
L
T
D
K
D
V
L
G
E
G
D
T
A
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
I82
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
93.3
93.3
80
13.3
N.A.
0
N.A.
0
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
93.3
20
N.A.
13.3
N.A.
33.3
33.3
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
0
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
54
7
40
7
0
7
0
14
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
54
7
20
14
7
0
0
14
0
0
7
0
7
% D
% Glu:
0
14
7
54
0
0
0
0
0
0
60
54
7
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
7
7
54
20
0
20
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
7
0
0
20
0
0
0
7
7
7
7
% I
% Lys:
7
7
0
14
0
14
0
0
0
0
0
7
7
7
0
% K
% Leu:
67
7
14
0
7
7
60
0
20
0
7
0
54
0
14
% L
% Met:
0
7
0
0
0
0
0
0
7
7
7
0
0
0
7
% M
% Asn:
0
0
0
0
54
0
7
7
7
60
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
7
14
0
0
7
7
20
0
0
0
0
0
7
7
% S
% Thr:
20
54
7
14
7
0
7
0
0
0
20
14
7
60
0
% T
% Val:
0
0
0
0
0
7
0
7
7
0
0
0
0
0
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _